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PancreasThe pancreas is a small organ found near the stomach that has two main roles in the body:

  • Endocrine role - this means that it releases hormones into the bloodstream, in this case beta-cells release insulin (which lowers blood glucose) and alpha-cells release glucagon (which raises blood glucose by releasing it from stores).

  • Exocrine role - this means that it releases enzymes via a duct into the small intestine for digestion of fats and proteins.  This shouldn’t affect hyperinsulinism patients unless they have a near-total pancreatectomy, in which case they will need to take enzyme-replacements with their meals.

In hyperinsulinism the endocrine function, specifically the beta-cells are affected.  

In the focal form of the disease the affected cells are located together in a cluster.  This focus is generally spherical between 2-10mm but can be much bigger or even have an “octopus” shape.  If the focus is removed this should cure the hyperinsulinism.

In the diffuse form all the beta cells in the pancreas are affected.  Therefore treatment aims to stop all of these cells producing too much insulin.  This is done through medication.  If this fails then doctors may decide to remove most of the pancreas. However this does not remove all the beta cells and the hyperinsulinism may persist.

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The Children's Hyperinsulinism Charity
Registered Charity Number: 1165562

The CHC is set up by parents for parents

For any medical advice, you should always contact your specialist medical team.

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